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Article

Optimum culture conditions for the epoxidation of cis-propenylphosphonate to fosfomycin by Cellvibrio gilvus.

Applied microbiology and biotechnology - 1 Jan 1992

Aisaka K, Ohshiro T, Uwajima T

Abstract excerpt

Approximately 470 strains of various microorganisms were tested for their ability to epoxidize cis-propenylphosphonate (PPOH) to (-)-cis-1,2-epoxypropylphosphonate (fosfomycin, FOM). Cellvibrio gilvus KY 3412 was selected as the best strain. To obtain higher activity, FOM-resistant strains were d...

Topics

Cobalt
Culture Media
Epoxy Compounds
Fosfomycin
Gram-Negative Aerobic Bacteria
Hydrogen-Ion Concentration
Methylnitronitrosoguanidine
Mutagenesis
Mutation
Organophosphonates
Organophosphorus Compounds
Technology, Pharmaceutical

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PMID: 1368198
DOI: 10.1007/BF00170177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1368198-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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