Article
Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26).
American journal of human genetics - 1 Nov 2003
Zhu M, Yang T, Wei S, DeWan A T, Morell R J, Elfenbein J L, Fisher R A, Leal S M, Smith R J H, Friderici K H
Abstract excerpt
Age-related hearing loss (presbycusis) is a significant problem in the population. The genetic contribution to age-related hearing loss is estimated to be 40%-50%. Gene mutations that cause nonsyndromic progressive hearing loss with early onset may provide insight into the etiology of presbycusis. We have identified four families segregating an autosomal dominant, progressive, sensorineural hearing loss phenotype...
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