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Article

Activin βC-Subunit Heterodimers Provide a New Mechanism of Regulating Activin Levels in the Prostate

1 Jul 2003

Abstract excerpt

Activins are formed by dimerization of beta-subunits and, as members of the TGF-beta superfamily, have diverse roles as potent growth and differentiation factors. As the biological function of the activin C homodimer (betaC-betaC) is unknown, we sought to compare activin A (betaA-betaA), B (betaB-betaB), and C homodimer bioactivities and to investigate the consequences of activin betaC-subunit overexpression in...

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PMID: 12960042
DOI: 10.1210/en.2003-0225

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