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Article

Diversity of core antigen epitopes of hepatitis B virus

3 Sept 2003

Abstract excerpt

Core antigen (cAg), the viral capsid, is one of the three major clinical antigens of hepatitis B virus. cAg has been described as presenting either one or two conformational epitopes involving the "immunodominant loop." We have investigated cAg antigenicity by cryo-electron microscopy at approximately 11-A resolution of capsids labeled with monoclonal Fabs, combined with molecular modeling, and describe here two...

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PMID: 12954985
DOI: 10.1073/pnas.1834404100

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