Article
Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.
Immunity - 1 Aug 2003
Layer Katrin, Lin Guosheng, Nencioni Alessio, Hu Wei, Schmucker Adam, Antov Andrey N, Li Xiaoyu, Takamatsu Satoshi, Chevassut Timothy, Dower Nancy A, Stang Stacey L, Beier David, Buhlmann Janet, Bronson Roderick T, Elkon Keith B, Stone James C, Van Parijs Luk, Lim Bing
Abstract excerpt
A mouse strain was identified with a recessive genetic lesion, which spontaneously developed a lymphoproliferative autoimmune syndrome exhibiting features of systemic lupus erythematosus. Positional mapping of the disease-associated locus revealed a lesion in Rasgrp1 that prevented the translation of the RasGRP1 protein. T cells from these mice failed to activate Ras or proliferate vigorously following antigen...
Read the complete abstract on PubMedTopics
- Animals
- Apoptosis
- Autoimmune Diseases
- Autoimmunity
- B-Lymphocytes
- CD4-Positive T-Lymphocytes