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Case-Crossover and Case-Time-Control Designs in Birth Defects Epidemiology

14 Aug 2003

Abstract excerpt

The case-crossover and the case-time-control designs can be used to evaluate the effect of intermittent exposures on the risk of acute events. To explore how birth defects epidemiology could benefit from these approaches, the authors compared them with a traditional case-control study design that evaluated the association between use of folic acid antagonists during the second and third pregnancy months and the...

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PMID: 12915504
DOI: 10.1093/aje/kwg144

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