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Genomic microarrays in human genetic disease and cancer

5 Aug 2003

Abstract excerpt

Alterations in the genome that lead to changes in DNA sequence copy number are a characteristic of solid tumors and are found in association with developmental abnormalities and/or mental retardation. Comparative genomic hybridization (CGH) can be used to detect and map these changes. Recent improvements in the resolution and sensitivity of CGH have been possible through implementation of microarray-based CGH...

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Share to Chromosomal and Genetic Variations
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PMID: 12915456
DOI: 10.1093/hmg/ddg261

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