Article
Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus.
BMC genetics - 28 Jun 2003
Doney Alex S F, Fischer Bettina, Cecil Joanne E, Cohen Patricia T W, Boyle Douglas I, Leese Graham, Morris Andrew D, Palmer Colin N A
Abstract excerpt
BACKGROUND: The ARE insertion/deletion polymorphism of PPP1R3A has been associated with variation in glycaemic parameters and prevalence of diabetes. We have investigated its role in age of diagnosis, body weight and glycaemic control in 1,950 individuals with type 2 diabetes in Tayside, Scotland, and compared the ARE2 allele frequencies with 1,014 local schoolchildren. RESULTS: Men homozygous for the rarer...
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