Article
The two size alleles of human keratin 1 are due to a deletion in the glycine-rich carboxyl-terminal V2 subdomain.
The Journal of investigative dermatology - 1 Dec 1992
Korge B P, Compton J G, Steinert P M, Mischke D
Abstract excerpt
Two size variants of the type II human keratin 1 protein chain, termed 1a and 1b, have been described previously. Using amplification of genomic DNA by the polymerase chain reaction and sequence analysis we show here that the difference between these two alleles is due to a deletion of 21 bp in s...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Humans
- Keratins
- Molecular Sequence Data
- Polymorphism, Genetic