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Article

Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human

1 Jul 2003

Abstract excerpt

The CCND1-ORAOV1-FGF19-FGF4-FGF3-FLJ10261-FADD-PPFIA1-EMS1 locus on human chromosome 11q13 is frequently amplified in esophageal cancer, breast cancer, and bladder tumors. FGF19, FGF4 and FGF3 genes are implicated in embryogenesis and carcinogenesis. We proposed in 2002 the hypothesis that mouse Fgf15 might be the ortholog of human FGF19 based on comparative genomics. Here, we identified zebrafish fgf19 and...

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PMID: 12792807
DOI: 10.3892/ijmm.12.1.45

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