Article
Null mutation of the arginine-vasopressin gene in rats slows attentional engagement and facilitates response accuracy in a lateralized reaction time task.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2003
Jentsch J David, Arguello P Alexander, Anzivino Luigi A
Abstract excerpt
The neurophysin vasopressin is thought to play an important role in emotional behavior and aspects of cognition in the rat, and the pathophysiology of this system has been implicated in two neurodevelopmental disorders, namely autism and schizophrenia. Genetic deficiency of vasopressin in rats, resulting from a null mutation of the vasopressin gene, causes alterations of brain development with resulting...
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