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Article

Ehlers-Danlos syndrome with severe early-onset periodontal disease (EDS-VIII) is a distinct, heterogeneous disorder with one predisposition gene at chromosome 12p13.

American journal of human genetics - 1 Jul 2003

Rahman Nazneen, Dunstan Melanie, Teare M Dawn, Hanks Sandra, Douglas Jenny, Coleman Kim, Bottomly William E, Campbell Mary E, Berglund Britta, Nordenskjöld Magnus, Forssell Bengt, Burrows Nigel, Lunt Peter, Young Ian, Williams Nigel, Bignell Graham R, Futreal P Andrew, Pope F Michael

Abstract excerpt

Ehlers-Danlos VIII (EDS-VIII) is an autosomal dominant disorder characterized by severe early-onset periodontal disease in conjunction with the features of Ehlers-Danlos syndrome (EDS). We performed a genomewide linkage search in a large Swedish pedigree with EDS-VIII and established linkage to a 7-cM interval on chromosome 12p13, generating a maximum multipoint LOD score of 5.17. Analysis of four further...

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PMID: 12776252
DOI: 10.1086/376416
PMCID: PMC1180581

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Source receipt: pubmed, retrieved 7 Sept 2026.

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