Article
High rate of constitutional chromosomal rearrangements in apparently sporadic ALS.
Neurology - 22 Apr 2003
Meyer T, Alber B, Roemer K, Martin T, Kalscheuer V M, Göttert E, Zang K D, Ludolph A C, Ropers H-H, Prudlo J
Abstract excerpt
Of 85 patients with ALS, the authors identified 3 patients with balanced translocations and 2 patients with pericentric inversions, all affecting distinct chromosomal loci. The high rate of constitutional aberrations (5.9%) suggests that ALS is, in part, associated with recombination-based rearra...
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