Effect of heterogeneity of rabies virus strain and challenge route on efficacy of inactivated rabies vaccines in mice.

Abstract excerpt

OBJECTIVE: To determine effect of route of challenge and strain of rabies virus on efficacy of inactivated rabies vaccines in mice. ANIMALS: 3,056 mice. PROCEDURE: Challenge was performed with fixed and street rabies virus strains by use of footpad and intracerebral routes as well as IM injection into the hip, shoulder, neck, and masseter muscles. Intraperitoneal and IM vaccination was performed with 1 or 2 doses...

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