Article
Novel surrogate end-point biomarker to evaluate agents for use in the chemoprevention of reactive oxygen species-associated cancer.
Redox report : communications in free radical research - 1 Jan 2002
Hiroyasu Makoto, Ozeki Munetaka, Miyagawa-Hayashino Aya, Fujiwara Yoshie, Hiai Hiroshi, Toyokuni Shinya
Abstract excerpt
Cancer chemoprevention is the use of chemical agents to inhibit, delay or reverse carcinogenesis. We established a novel method to evaluate agents for use in the chemoprevention of reactive oxygen species (ROS)-associated cancer. Induction of renal cell carcinoma in rats by ferric nitrilotriacetate (Fe-NTA) is an established model of ROS-associated cancer. We recently identified the p16INK4A tumor suppressor gene...
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