Article
Association of inflammatory bowel disease with indicators for childhood antigen and infection exposure.
International journal of colorectal disease - 1 Sept 2003
Hampe Jochen, Heymann Kerstin, Krawczak Michael, Schreiber Stefan
Abstract excerpt
BACKGROUND AND AIMS: Genetic susceptibility plays an important role in the predisposition to inflammatory bowel disease (IBD), but genetics alone cannot explain the six- to eightfold rise in incidence accompanying postwar socioeconomic changes in developed countries. It is presently unclear how environmental factors either trigger or modify the risk for and course of IBD in the presence of genetic susceptibility....
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