Article
Neuropathological features of a case with schizophrenia and prion protein gene P102L mutation before onset of Gerstmann-Sträussler-Scheinker disease.
Acta neuropathologica - 1 Jul 2003
Sasaki Kensuke, Doh-ura Katsumi, Furuta Akiko, Nakashima Sachi, Morisada Yumi, Tateishi Jun, Iwaki Toru
Abstract excerpt
Gerstmann-Sträussler-Scheinker disease (GSS) is a hereditary transmissible spongiform encephalopathy associated with prion protein gene mutation P102L. The age of onset is roughly restricted to around the sixth decade; however, it is unclear whether the disease-specific pathology of GSS is already evident in the pre-clinical stage. We had a chance to examine an autopsy case with PRNP P102L mutation. The patient...
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