Article
Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003
State Matthew W, Greally John M, Cuker Adam, Bowers Peter N, Henegariu Octavian, Morgan Thomas M, Gunel Murat, DiLuna Michael, King Robert A, Nelson Carol, Donovan Abigail, Anderson George M, Leckman James F, Hawkins Trevor, Pauls David L, Lifton Richard P, Ward David C
Abstract excerpt
Gilles de la Tourette syndrome (GTS) is a potentially debilitating neuropsychiatric disorder defined by the presence of both vocal and motor tics. Despite evidence that this and a related phenotypic spectrum, including chronic tics (CT) and Obsessive Compulsive Disorder (OCD), are genetically mediated, no gene involved in disease etiology has been identified. Chromosomal abnormalities have long been proposed to...
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