Article
Germline mutations in fumarate hydratase (FH) do not predispose to prostate cancer.
Prostate cancer and prostatic diseases - 1 Jan 2003
Bevan S, Edwards S M, Ardern Jones A, Dowe A, Southgate C, Dearnaley D, Easton D F, Houlston R S, Eeles R A
Abstract excerpt
Inherited susceptibility to prostate cancer has been linked to a number of chromosomal regions, however no genes have been unequivocally shown to underlie reported linkages. The putative gene localised to chromosome 1q42-q43, has been designated PCaP. We have recently shown that germline mutations in the fumarate hydratase (FH) gene located on 1q43 cause smooth muscle tumours and renal cell carcinoma. It is...
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