Article
A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding.
Human molecular genetics - 15 Mar 2003
Lyon Mary F, Jamieson Robyn V, Perveen Rahat, Glenister Peter H, Griffiths Robert, Boyd Yvonne, Glimcher Laurie H, Favor Jack, Munier Francis L, Black Graeme C M
Abstract excerpt
The murine autosomal dominant cataract mutants created in mutagenesis experiments have proven to be a powerful resource for modelling the biological processes involved in cataractogenesis. We report a mutant which in the heterozygous state exhibits mild pulverulent cataract named 'opaque flecks in lens', symbol Ofl. By molecular mapping, followed by a candidate gene approach, the mutant was shown to be allelic...
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