Article
Association of the vitamin D receptor genotype with bone metastases in breast cancer patients.
Oncology - 1 Jan 2003
Schöndorf Thomas, Eisberg Carsten, Wassmer Gernot, Warm Mathias, Becker Martina, Rein Daniel T, Göhring Uwe-Jochen
Abstract excerpt
This study was designed in order to evaluate specific vitamin D receptor (VDR) genotypes as indicators of the likelihood of developing osseous metastases in breast cancer patients. Therefore, we determined polymorphisms of the VDR gene in a study group comprising 183 breast cancer patients. Specific fragments spanning over intron 8 and exon 9 of the VDR gene were amplified by polymerase chain reaction. The...
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