Article
Low nuclear proliferative activity is associated with nonmetastatic islet cell tumors.
Archives of pathology & laboratory medicine - 1 Feb 2003
Jorda Merce, Ghorab Zeina, Fernandez Gustavo, Nassiri Mehdi, Hanly Andrew, Nadji Mehrdad
Abstract excerpt
CONTEXT: Traditional morphologic features of tumor aggression are of limited value in predicting the malignant behavior of endocrine neoplasms. We explored the potential value of nuclear proliferative activity (using Ki-67 immunostaining with semiquantitative scoring) in predicting the clinical behavior of pancreatic islet cell tumors (ICTs), and we correlated this characteristic with hormone expression....
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