Article
Association of EEG coherence and an exonic GABA(B)R1 gene polymorphism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Feb 2003
Winterer Georg, Smolka Michael, Samochowiec Jerzy, Ziller Mario, Mahlberg Richard, Gallinat Jürgen, Rommelspacher Hans-Peter, Herrmann Werner M, Sander Thomas
Abstract excerpt
The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for epilepsy and schizophrenia have been mapped in this region. Based on pharmacological evidence, it has been suggested that GABA(B) receptors may play a crucial role in the synchronization of EEG oscillations, which in turn can be abnormal in neuropsychiatric disorders. In the...
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