Chromosome 15 maternal uniparental disomy and psychosis in Prader-Willi syndrome

Abstract excerpt

In the 16 January 2002 issue of the Lancet , Boer et al 1 reported that psychotic illness in Prader-Willi syndrome (PWS) is associated with chromosome 15 maternal uniparental disomy. Here, we report the findings of a 10 year follow up study at the Centre for Human Genetics in Leuven, confirming the results of the previous study. Fifty-nine PWS patients with the diagnosis confirmed by DNA methylation testing had...

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