Article
Lack of association between Y chromosome haplogroups and male infertility in Japanese men.
American journal of medical genetics. Part A - 15 Jan 2003
Carvalho Cláudia M B, Fujisawa Masato, Shirakawa Toshiro, Gotoh Akinobu, Kamidono Sadao, Freitas Paulo Tatiana, Santos Sidney E B, Rocha Juliane, Pena Sérgio D J, Santos Fabrício R
Abstract excerpt
The Y chromosome carries several genes involved in spermatogenesis, which are distributed in three regions in the euchromatic part of the long arm, called AZFa (azoospermia factor a), AZFb, and AZFc. Microdeletions in these regions have been seen in 10-15% of sterile males with azoospermia or severe oligozoospermia. The relatively high de novo occurrence of these microdeletion events might be due to particular...
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