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Article

Overcoming Immunity to a Viral Vaccine by DNA Priming before Vector Boosting

11 Dec 2002

Abstract excerpt

Replication-defective adenovirus (ADV) and poxvirus vectors have shown potential as vaccines for pathogens such as Ebola or human immunodeficiency virus in nonhuman primates, but prior immunity to the viral vector in humans may limit their clinical efficacy. To overcome this limitation, the effect of prior viral exposure on immune responses to Ebola virus glycoprotein (GP), shown previously to protect against...

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PMID: 12477888
DOI: 10.1128/jvi.77.1.799-803.2003

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