Article
Within-breed heterozygosity of canine single nucleotide polymorphisms identified by across-breed comparison.
Animal genetics - 1 Dec 2002
Brouillette J A, Venta P J
Abstract excerpt
Identification of single nucleotide polymorphisms (SNPs) by DNA sequence comparison across breeds is a strategy for developing genetic markers that are useful for many breeds. However, the heterozygosity of SNPs identified in this way might be severely reduced within breeds by inbreeding or genetic drift in the small effective population size of a breed (population subdivision). The effect of inbreeding and...
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