Article
Primary dystonia: is abnormal functional brain architecture linked to genotype?
Annals of neurology - 1 Dec 2002
Trost Maja, Carbon Maren, Edwards Christine, Ma Yilong, Raymond Deborah, Mentis Marc J, Moeller James R, Bressman Susan B, Eidelberg David
Abstract excerpt
The DYT1 dystonia mutation is associated with an abnormal metabolic brain network characterized by hypermetabolism of the basal ganglia, supplementary motor area, and the cerebellum. In this study, we quantified the activity of this network in carriers of other dystonia mutations to determine whether this functional abnormality is linked to genotype. The findings suggest that the DYT1 metabolic topography is not...
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