Article
Interleukin 4 receptor on human lung cancer: a molecular target for cytotoxin therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2002
Kawakami Mariko, Kawakami Koji, Stepensky Vitaly A, Maki Richard A, Robin Howard, Muller Wayne, Husain Syed R, Puri Raj K
Abstract excerpt
Previous studies have demonstrated that human lung tumor cell lines express interleukin 4 (IL-4) receptors, and IL-4 can mediate modest to moderate antiproliferative activity in vitro and in vivo in animal models of human lung tumors. On the basis of these studies, IL-4 was tested in clinical trials; however, it showed little antitumor activity in lung cancer patients. In the present study, we examined the...
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