Article
Essential histidine and tryptophan residues in CcsA, a system II polytopic cytochrome c biogenesis protein.
The Journal of biological chemistry - 24 Jan 2003
Hamel Patrice P, Dreyfuss Beth Welty, Xie Zhiyi, Gabilly Stéphane T, Merchant Sabeeha
Abstract excerpt
Three distinct systems (I, II, and III) for catalysis of heme attachment to c-type apocytochromes are known. The CcsA and Ccs1 proteins are required in system II for the assembly of bacterial and plastid cytochromes c. A tryptophan-rich signature motif (WWD), also occurring in CcmC and CcmF found in system I, and three histidinyl residues, all strictly conserved in CcsA suggest a function in heme handling....
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