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Article

Long-term divergent selection on fatness in mice indicates a regulation system independent of leptin production and reception.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2003

Bünger Lutz, Forsting Jürgen, McDonald Katharine L, Horvat Simon, Duncan Jackie, Hochscheid Sandra, Baile Clifton A, Hill William G, Speakman John R

Abstract excerpt

Divergent selection in mice on fatness over 60 generations produced a fat (F) and a lean (L) line, having about 22% and 4% body fat, respectively. To elucidate the importance of the leptin regulatory feedback loop in the genetic changes produced by this selection, Lep(ob) and Lepr(db) mutations causing leptin production and leptin receptor deficiency, respectively, were introgressed individually into both lines...

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Identifiers

PMID: 12424222
DOI: 10.1096/fj.02-0111fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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