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Article

Recombinant Respiratory Syncytial Virus with the G and F Genes Shifted to the Promoter-Proximal Positions

1 Nov 2002

Abstract excerpt

The genome of human respiratory syncytial virus (RSV) encodes 10 mRNAs and 11 proteins in the order 3'-NS1-NS2-N-P-M-SH-G-F-M2-1/M2-2-L-5'. The G and F glycoproteins are the major RSV neutralization and protective antigens. It seems likely that a high level of expression of G and F would be desirable for a live RSV vaccine. For mononegaviruses, the gene order is a major factor controlling the level of mRNA and...

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Identifiers

PMID: 12414935
DOI: 10.1128/jvi.76.23.11931-11942.2002

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