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Article

Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis.

American journal of respiratory cell and molecular biology - 1 Nov 2002

Ramalho Anabela S, Beck Sebastian, Meyer Michelle, Penque Deborah, Cutting Garry R, Amaral Margarida D

Abstract excerpt

Estimates of the level of transcripts from the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene required to develop a CF phenotype range from 4-20% of normal. Due to the importance of obtaining reliable data on this issue for therapeutic strategies, we developed a novel polymerase chain reaction-based method to quantify CFTR transcripts and applied it to the analysis of nasal epithelium RNA of...

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Source

Identifiers

PMID: 12397022
DOI: 10.1165/rcmb.2001-0004OC

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis.PMID 12397022Read ↗

Assessing the residual CFTR gene expression in human nasal epithelium cells bearing CFTR splicing mutations causing cystic fibrosis.Semantic proximity Read ↗

Quantification of CFTR transcripts.Semantic proximity Read ↗

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Features of CFTR mRNA and implications for therapeutics developmentSemantic proximity Read ↗

The molecular basis of disease variability among cystic fibrosis patients carrying the 3849+10 kb C-->T mutation.Semantic proximity Read ↗

Variable levels of normal RNA in different fetal organs carrying a cystic fibrosis transmembrane conductance regulator splicing mutation.Semantic proximity Read ↗

Respiratory Epithelial Gene Expression in Patients with Mild and Severe Cystic Fibrosis Lung DiseaseSemantic proximity Read ↗

Molecular and functional analysis of the large 5' promoter region of CFTR gene revealed pathogenic mutations in CF and CFTR-related disorders.Semantic proximity Read ↗

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Large variations in total and allele-specific transcript expression in a disease mutation-independent manner.Semantic proximity Read ↗

Qualitative and quantitative analysis of mRNA associated with four putative splicing mutations (621+3A-->G, 2751+2T-->A, 296+1G-->C, 1717-9T-->C-D565G) and one nonsense mutation (E822X) in the CFTR gene.Semantic proximity Read ↗

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