Article
Mutations in the rpoB and katG genes leading to drug resistance in Mycobacterium tuberculosis in Latvia.
Journal of clinical microbiology - 1 Oct 2002
Tracevska T, Jansone I, Broka L, Marga O, Baumanis V
Abstract excerpt
To characterize the genetic basis of drug resistance in Mycobacterium tuberculosis in Latvia, mutations involved in rifampin (rpoB gene) and isoniazid (katG gene) resistance in DNA from 19 drug-susceptible and 51 multidrug-resistant M. tuberculosis complex isolates were analyzed. The most frequent rpoB gene mutations found by the Line Probe assay were the S531L (14 of 34 isolates), D516V (7 of 34), H526D (4 of...
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