Why are bacteria refractory to antimicrobials?

Abstract excerpt

The incidence of antibiotic resistance in pathogenic bacteria is rising. Antibiotic resistance can be achieved via three distinct routes: inactivation of the drug, modification of the target of action, and reduction in the concentration of drug that reaches the target. It has long been recognized that specific antibiotic resistance mechanisms can be acquired through mutation of the bacterial genome or by gaining...

Topics

• Anti-Bacterial Agents
• Bacteria
• Drug Resistance, Bacterial
• Gene Transfer, Horizontal
• Mutation