Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Origin and instability of GAA repeats: insights from Alu elements.

Journal of biomolecular structure & dynamics - 1 Oct 2002

Chauhan Chitra, Dash Debasis, Grover Deepak, Rajamani Jaya, Mukerji Mitali

Abstract excerpt

Expansion of GAA repeats in the intron of the frataxin gene is involved in the autosomal recessive Friedreich's ataxia (FRDA). The GAA repeats arise from a stretch of adenine residues of an Alu element. These repeats have a size ranging from 7- 38 in the normal population, and expand to thousands in the affected individuals. The mechanism of origin of GAA repeats, their polymorphism and stability are not well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Flanking Region
Share to Alu Elements
Share to Chromosomes, Human, Pair 22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frataxin

Share to Friedreich Ataxia

Share to Iron-Binding Proteins

Share to Trinucleotide Repeat Expansion

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 12354077
DOI: 10.1080/07391102.2002.10506841

Genes

GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Origin and instability of GAA repeats: insights from Alu elements.PMID 12354077Read ↗

Expansion of GAA triplet repeats in the human genome: unique origin of the FRDA mutation at the center of an Alu.Semantic proximity Read ↗

The Friedreich ataxia GAA triplet repeat: premutation and normal alleles.Semantic proximity Read ↗

Large Interruptions of GAA Repeat Expansion Mutations in Friedreich Ataxia Are Very RareSemantic proximity Read ↗

New clues on the origin of the Friedreich ataxia expanded alleles from the analysis of new polymorphisms closely linked to the mutation.Semantic proximity Read ↗

Evolution of the Friedreich's ataxia trinucleotide repeat expansion: founder effect and premutations.Semantic proximity Read ↗

GAA instability in Friedreich's Ataxia shares a common, DNA-directed and intraallelic mechanism with other trinucleotide diseases.Semantic proximity Read ↗

Phylogenetic analysis of the Friedreich ataxia GAA trinucleotide repeat.Semantic proximity Read ↗

Expansion of GAA trinucleotide repeats in mammals.Semantic proximity Read ↗

Comparative Analysis of TG/CA Repeats in Sixteen Primate Genomes Reveals the Dynamics and Role of TG/CA Repeats in the Human GenomeSemantic proximity Read ↗

The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion.Semantic proximity Read ↗

Somatic instability of the expanded GAA repeats in Friedreich’s ataxiaSemantic proximity Read ↗

Interruptions of the FXN GAA Repeat Tract Delay the Age at Onset of Friedreich's Ataxia in a Location Dependent Manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.