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Article

The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion

19 Sept 2002

Abstract excerpt

In the Chapel Hill colony of factor VIII-deficient dogs, abnormal sequence (ch8, for canine hemophilia 8, GenBank no. ) follows exons 1-22 in the factor VIII transcript in place of exons 23-26. The canine hemophilia 8 locus (ch8) sequence was found in a 140-kb normal dog genomic DNA bacterial artificial chromosome (BAC) clone that was completely outside the factor VIII gene, but not in BAC clones containing the...

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PMID: 12242334
DOI: 10.1073/pnas.192219599

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