Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.

doi:10.1172/JCI15795

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Article

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.

The Journal of clinical investigation - 1 Sept 2002

Signoretti Sabina, Di Marcotullio Lucia, Richardson Andrea, Ramaswamy Sridhar, Isaac Beth, Rue Montserrat, Monti Franco, Loda Massimo, Pagano Michele

Abstract excerpt

Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the ubiquitin-mediated degradation of the cdk-inhibitor p27 and is a bona fide proto-oncoprotein. Using microarray analysis and immunohistochemistry, we determined that higher levels of Skp2 are present more frequently in...

Read the complete abstract on PubMed

Topics

Breast Neoplasms
Cell Adhesion
Cell Cycle
Cell Cycle Proteins
Cell Division
Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Transfer Techniques

Humans

Immunohistochemistry

Microscopy, Fluorescence

Oligonucleotide Array Sequence Analysis

Phenotype

Receptors, Estrogen

Retroviridae

S-Phase Kinase-Associated Proteins

Time Factors

Tumor Cells, Cultured

Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12208864
DOI: 10.1172/JCI15795
PMCID: PMC151109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.