Article
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia.
Cancer cell - 1 Aug 2002
Shah Neil P, Nicoll John M, Nagar Bhushan, Gorre Mercedes E, Paquette Ronald L, Kuriyan John, Sawyers Charles L
Abstract excerpt
Through sequencing analysis of blood or bone marrow samples from patients with chronic myeloid leukemia, we identified BCR-ABL kinase domain mutations in 29 of 32 patients whose disease relapsed after an initial response to the tyrosine kinase inhibitor imatinib. Fifteen different amino acid subs...
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