Article
Prevalence of G333D/E in naive and pretreated HIV-infected patients.
AIDS research and human retroviruses - 10 Aug 2002
Gallego Oscar, Corral Angélica, de Mendoza Carmen, Rodés Berta, Soriano Vincent
Abstract excerpt
A substitution at codon 333 (G -->D/E) within the reverse transcriptase (RT) gene causes resistance to both zidovudine (AZT) and lamivudine (3TC) in a background of mutations associated with loss of sensitivity to both drugs. In the absence of G333D/E, M184V restores the sensitivity to AZT in viruses harboring AZT-resistant genotypes. In this study, we examined the prevalence of the G333D/E mutation in plasma...
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