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Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts

28 Aug 2002

Abstract excerpt

Fetal cells, specifically fetal erythroblasts, as well as cell-free fetal DNA are present in the maternal circulation. Both are currently being investigated as a means for the non-invasive risk-free analysis of fetal genetic traits. The origin of this cell-free fetal DNA in the maternal circulation is currently unclear. Since numerous fetal erythroblasts have been demonstrated to exhibit an apoptotic phenotype in...

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PMID: 12200465
DOI: 10.1093/molehr/8.9.864

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