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Article

Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myeloma

29 Aug 2002

Abstract excerpt

Complete or partial deletion of chromosome 13 or translocations involving 13q (delta13) by conventional cytogenetic analysis confers a poor prognosis in multiple myeloma (MM) patients, even with timely application of tandem autologous transplants. It was recently suggested that the prognostic significance of delta13 is related to its frequent association with hypodiploidy but by itself does not have a poor...

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Identifiers

PMID: 12199783
DOI: 10.1046/j.1365-2141.2002.03757.x

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Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myelomaPMID 12199783Read ↗

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The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myelomaSemantic proximity Read ↗

Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: interpretation in the context of global gene expressionSemantic proximity Read ↗

Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalitiesSemantic proximity Read ↗

Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapySemantic proximity Read ↗

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Chromosome 13 deletion and hypodiploidy on conventional cytogenetics are robust prognostic factors in Korean multiple myeloma patients: web-based multicenter registry studySemantic proximity Read ↗

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