Article
Candidate genes for osteoporosis. Therapeutic implications.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2001
Niu T, Xu X
Abstract excerpt
Osteoporosis, which afflicts 10 million Americans, is a complex disease characterized by decreased bone mass, microarchitectural deterioration of bone tissue, and an increase in fracture risk. Family and twin studies have established a genetic contribution to the etiology of osteoporosis. The biological candidate genes of osteoporosis can be ordered into 5 categories: (i) calcium homeostasis; (ii) hormonal...
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