Article
Impact of thrombophilic gene mutations on thrombosis risk in patients with gastrointestinal carcinoma.
Cancer - 15 Jun 2002
Pihusch Rudolf, Danzl Gudrun, Scholz Michael, Harich Detlev, Pihusch Markus, Lohse Peter, Hiller Erhard
Abstract excerpt
BACKGROUND: Patients with malignancies have an increased risk for thromboembolic events due to the release of tissue factor by the tumor, damage to the vessel wall, and immobilization. Moreover, tumors may improve their growth and metastatic spread by utilizing the coagulation system. To date, no information is available on the additional role of prothrombotic mutations in these patients. METHODS: The prevalence...
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