Article
Molecular basis of an inherited epilepsy.
Neuron - 13 Jun 2002
Lossin Christoph, Wang Dao W, Rhodes Thomas H, Vanoye Carlos G, George Alfred L
Abstract excerpt
Epilepsy is a common neurological condition that reflects neuronal hyperexcitability arising from largely unknown cellular and molecular mechanisms. In generalized epilepsy with febrile seizures plus, an autosomal dominant epilepsy syndrome, mutations in three genes coding for voltage-gated sodium channel alpha or beta1 subunits (SCN1A, SCN2A, SCN1B) and one GABA receptor subunit gene (GABRG2) have been...
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