Article
MHC class I chain-related gene a alleles distinguish malnutrition-modulated diabetes, insulin-dependent diabetes, and non-insulin- dependent diabetes mellitus patients from eastern India.
Annals of the New York Academy of Sciences - 1 Apr 2002
Sanjeevi C B, Kanungo A, Berzina L, Shtauvere-Brameus A, Ghaderi M, Samal K C
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) is a polygenic disorder with an autoimmune basis for disease development. In addition to HLA, a second susceptibility locus for IDDM has been identified to lie in the major histocompatibility class III region. MIC-A is located in the MHC class III region and is expressed by monocytes, keratinocytes, and endothelial cells. Sequence determination of the MIC-A gene...
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