Article
Molecular cloning and expression of rat torsinA in the normal and genetically dystonic (dt) rat.
Brain research. Molecular brain research - 30 May 2002
Ziefer Philipp, Leung Joanne, Razzano Tara, Shalish Christo, LeDoux Mark S, Lorden Joan F, Ozelius Laurie, Breakefield Xandra O, Standaert David G, Augood Sarah J
Abstract excerpt
Deletions within the TOR1A gene cause early-onset (DYT1) torsion dystonia. We have cloned and sequenced the rat cDNA homologue of TOR1A and found a 91% identity with the human sequence. Northern blot analysis detects a single transcript of approximately 1.5 kb. In situ hybridization reveals a widespread distribution of torsinA mRNA within brain. No mutations were identified in the coding region of the gene in the...
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