Pathophysiology of Dyt1- Tor1a dystonia in mice is mediated by spinal neural circuit dysfunction

Abstract excerpt

Dystonia, a neurological disorder defined by abnormal postures and disorganized movements, is considered to be a neural circuit disorder with dysfunction arising within and between multiple brain regions. Given that spinal neural circuits constitute the final pathway for motor control, we sought to determine their contribution to this movement disorder. Focusing on the most common inherited form of dystonia in...

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