Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of the membrane anchor of the target receptor is a mechanism of bioinsecticide resistance.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Darboux Isabelle, Pauchet Yannick, Castella Claude, Silva-Filha Maria Helena, Nielsen-LeRoux Christina, Charles Jean-François, Pauron David

Abstract excerpt

The mosquitocidal activity of Bacillus sphaericus is because of a binary toxin (Bin), which binds to Culex pipiens maltase 1 (Cpm1), an alpha-glucosidase present in the midgut of Culex pipiens larvae. In this work, we studied the molecular basis of the resistance to Bin developed by a strain (GEO) of C. pipiens. Immunohistochemical and in situ hybridization experiments showed that Cpm1 was undetectable in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insecta
Share to alpha-Glucosidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacterial Toxins

Share to Glycosylphosphatidylinositols

Share to Insecticide Resistance

Share to Phosphatidylinositol Diacylglycerol-Lyase

Share to Type C Phospholipases

Source

Open in PubMed Open full text

Identifiers

PMID: 11983886
DOI: 10.1073/pnas.092615399
PMCID: PMC122862

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of the membrane anchor of the target receptor is a mechanism of bioinsecticide resistance.PMID 11983886Read ↗

The receptor of Bacillus sphaericus binary toxin in Culex pipiens (Diptera: Culicidae) midgut: molecular cloning and expressionSemantic proximity Read ↗

A second independent resistance mechanism to Bacillus sphaericus binary toxin targets its alpha-glucosidase receptor in Culex quinquefasciatus.Semantic proximity Read ↗

Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens (Diptera: Culicidae).Semantic proximity Read ↗

The N-terminal third of the BinB subunit from the Bacillus sphaericus binary toxin is sufficient for its interaction with midgut receptors in Culex quinquefasciatus.Semantic proximity Read ↗

Binding of purified Bacillus sphaericus binary toxin and its deletion derivatives to Culex quinquefasciatus gut: elucidation of functional binding domains.Semantic proximity Read ↗

Culex pipiens pallens cuticular protein CPLCG5 participates in pyrethroid resistance by forming a rigid matrixSemantic proximity Read ↗

Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection.Semantic proximity Read ↗

Targeted mutagenesis at charged residues in Bacillus sphaericus BinA toxin affects mosquito-larvicidal activity.Semantic proximity Read ↗

Complexin in ivermectin resistance in body liceSemantic proximity Read ↗

Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.Semantic proximity Read ↗

A Bacillus thuringiensis Chitin-Binding Protein is Involved in Insect Peritrophic Matrix Adhesion and Takes Part in the Infection Process.Semantic proximity Read ↗

Highly Effective Broad Spectrum Chimeric Larvicide That Targets Vector Mosquitoes Using a Lipophilic ProteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.