Article
Phenotypic or genotypic resistance testing for choosing antiretroviral therapy after treatment failure: a randomized trial.
AIDS (London, England) - 29 Mar 2002
Meynard Jean-Luc, Vray Muriel, Morand-Joubert Laurence, Race Esther, Descamps Diane, Peytavin Gilles, Matheron Sophie, Lamotte Claire, Guiramand Sonia, Costagliola Dominique, Brun-Vézinet Françoise, Clavel François, Girard Pierre-Marie
Abstract excerpt
OBJECTIVE: To assess the respective value of phenotype versus genotype versus standard of care for choosing antiretroviral therapy in patients failing protease inhibitor-containing regimens. METHODS: Patients with plasma HIV-1 RNA exceeding 1000 copies/ml were randomly allocated to phenotyping, genotyping, or standard of care. RESULTS: Five-hundred and forty-one patients were randomized, 190 to phenotyping, 192...
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